Later that year, she appeared in the indie film Adam, with Hugh Dancy.
She appeared in the 2010 comedy film Get Him to the Greek, starring Russell Brand and Jonah Hill, and she was co-lead in the James Wan horror film Insidious, which premiered in September 2010 at the Toronto International Film Festival In 2013, Byrne appeared in the crime drama The Place Beyond the Pines, with Ryan Gosling and Bradley Cooper, and appeared in the comedy, The Internship, opposite Vince Vaughn and Owen Wilson; and The Turning, a short film installment in a Tim Winton omnibus feature.
Byrne revealed in a post-award interview that, prior to winning the Venice Film Festival Award, she was surprised by her own performance and found it confronting watching the film because her acting was "too depressing".
Byrne admitted that "watching myself is confronting because I'm convinced I can't act and I want to get out, that's how insecure I am." Byrne appeared as a guest in an episode of the police drama series Murder Call.
Byrne was last photographed in public on October 22 in New York City as she ran errands ahead of welcoming her new baby.
Speaking on The Late Show with Stephen Colbert, Cannavale said: 'We’re just really, really over the moon.
She is the youngest of their four children; she has an older brother, George, and two older sisters, Alice and Lucy.A remake of the 1982 classic, Annie, featured Byrne playing the role of Grace Farrell, Mr. Byrne's performance was mostly praised with reviewers calling her the surprise highlight of the movie.In 2015, Byrne co-starred with Melissa Mc Carthy, Jude Law and Jason Statham in the hit comedic action tale Spy, In 2016, Rebecca Skloot (author of The Immortal Life of Henrietta Lacks) announced that Byrne would be playing Skloot in the HBO film adaptation of her book.In 2006, Byrne portrayed Gabrielle de Polastron, duchesse de Polignac, a French aristocrat and friend of Marie Antoinette, in Sofia Coppola's Marie Antoinette, with Kirsten Dunst, and appeared in The Dead Girl, followed by Scarlett Ross, an army medical officer in Juan Carlos Fresnadillo's science fiction horror 28 Weeks Later, the sequel to Boyle's 28 Days Later; then appeared in the independent film Just Buried, She appeared in the Australian film noir The Tender Hook with Hugo Weaving in 2008.In 2009, Byrne co-starred with Nicolas Cage in the science fiction thriller Knowing.From 2007 to 2012, she played Ellen Parsons in the cable television series Damages, which earned her two Golden Globe Award and two Primetime Emmy Award nominations.Along with co-star Glenn Close, she appeared in all of the show's fifty-nine episodes.The film will also star Oprah Winfrey and Reneé Elise Goldsberry.She will be starring alongside Sandra Bullock, Rachel Weisz, Selena Gomez, Vanessa Hudgens, Zooey Deschanel, and Anna Kendrick in We Are Your Fist.In the 2003 release, she portrayed Rose Mortmain, the elder sister of Romola Garai's Cassandra.In 2003, she starred in three Australian films: The Night We Called It a Day with Melanie Griffith and Dennis Hopper; The Rage in Placid Lake for which she was named Best Actress at the Australian Film Institute; and Take Away, another comedy.